human CALR shRNA silencing Adenovirus

calregulin; calreticulin; cC1qR; CRP55; CRT; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; grp60; HACBP; HEL-S-99n; RO; Sicca syndrome antigen A (autoantigen Ro); SSA

Calreticulin is identified as a multifunctional protein that acts as a lectin chaperone and calcium binding protein. Calreticulin is found in the lumen of the endoplasmic reticulum and nucleus. In the nucleus, Calreticulin appears to function as a coregulator of nuclear hormone receptors. Increased autoantibody titers against calreticulin are associated with systemic lupus.

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

811

calreticulin

calreticulin

CALR

HGNC:1455

9606.0

1254

1254 bp

Calreticulin

NM_004343

NM_004343, BC020493, BC007911, BC002500,

Antigen Processing and Presentation,Apoptosis,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,DNA Replication,Gene Expression,Golgi Apparatus,Host-Virus Interactions,Immunology,Meiosis,Metabolism/Metabolic Process,mRNA Binding,Neurobiology,Neurodevelopment,Nuclear Import/Export,Protein Folding,Signal Transduction,Spermatogenesis,Transcription Factor/Regulator,Translational Control,Transport,TSH Signaling

signal_transduction,immunology,cell_biology,cardiovascular,cell_cycle,genetics,transcription_translation,cell_biology,infectious_disease,immunology,cell_biology,cell_cycle,metabolism,genetics,neurobiology,developmental_biology,cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,signal_transduction

human

Calreticulin is identified as a multifunctional protein that acts as a lectin chaperone and calcium binding protein. Calreticulin is found in the lumen of the endoplasmic reticulum and nucleus. In the nucleus, Calreticulin appears to function as a coregulator of nuclear hormone receptors. Increased autoantibody titers against calreticulin are associated with systemic lupus.

Hs.515162

P27797