human C2ORF42 shRNA silencing Adenovirus

Name 
Ad-h-C2ORF42-shRNA
Cat No 
shADV-203304
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TIA1.

shADV-203304
Ad-h-C2ORF42-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
nucleolysin TIA-1; nucleolysin TIA-1 isoform p40; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA-binding protein TIA-1; T-cell-restricted intracellular antigen-1; TIA-1; WDM
Description (eCommerce)
TIA-1 (T-cell-restricted intracellular antigen-1) is involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). TIA-1 possesses nucleolytic activity against cytotoxic lymphocyte target cells. It may be involved in apoptosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P31483].
Description (Vector)
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Gene ID
7072
Gene Name (eCommerce)
TIA1 cytotoxic granule associated RNA binding protein
Gene Name (Vector)
TIA1 cytotoxic granule associated RNA binding protein
Gene Symbol
TIA1
HGNC ID
HGNC:11802
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
645
Protein Name (eCommerce)
Nucleolysin TIA-1 isoform p40
RefSeq ID
NM_022173
RefSeq Synonyms
NM_022173, NM_022037, BC015944,
Research Areas
Apoptosis,Gene Expression,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome,Translational Control
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
TIA-1 (T-cell-restricted intracellular antigen-1) is involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). TIA-1 possesses nucleolytic activity against cytotoxic lymphocyte target cells. It may be involved in apoptosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P31483].
UniGene ID
Hs.413123
UniProt ID (eCommerce)
P31483

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.