human BAT3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human BAG6.
shADV-201979
Ad-h-BAT3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human BAG6 (BCL2 associated athanogene 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BAG family molecular chaperone regulator 6; BAG-6; BAT3; BCL2-associated athanogene 6; D6S52E; G3; HLA-B-associated transcript 3; large proline-rich protein BAG6; large proline-rich protein BAT3; protein G3; protein Scythe; scythe
Description (eCommerce)
HLA-B-associated transcript 3 was originally identified as a gene within the class III region of the major histocompatibility complex (MHC). In Xenopus, the homolog of BAT3 is known as Scythe. Scythe has been shown to play a role in the regulation of apoptosis. BAT3 is suggested to play a role in both proliferation and apoptosis, and it is suggested to influence these processes as a co-chaperone recruiter. BAT3 has been shown to be an essential regulator of the DNA damage-induced acetylation of p53 and the p53-mediated response to genotoxic stress.
Description (Vector)
BAG6 was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. BAG6 encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
7917
Gene Name (eCommerce)
BCL2 associated athanogene 6
Gene Name (Vector)
BCL2 associated athanogene 6
Gene Symbol
BAG6
HGNC ID
HGNC:13919
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3381
ORF Size (bp)
3381 bp
Protein Name (eCommerce)
Large proline-rich protein BAG6
RefSeq ID
NM_004639
RefSeq Synonyms
NM_080703, NM_080702, NM_004639, NM_001199698, NM_001199697, NM_001098534, BC003133,
Research Areas
Apoptosis,Brain Development,Chromatin Remodeling,Complexome,DNA Damage/Repair,Immunology,Neurobiology,Neurodevelopment,Proteasome,Spermatogenesis
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
HLA-B-associated transcript 3 was originally identified as a gene within the class III region of the major histocompatibility complex (MHC). In Xenopus, the homolog of BAT3 is known as Scythe. Scythe has been shown to play a role in the regulation of apoptosis. BAT3 is suggested to play a role in both proliferation and apoptosis, and it is suggested to influence these processes as a co-chaperone recruiter. BAT3 has been shown to be an essential regulator of the DNA damage-induced acetylation of p53 and the p53-mediated response to genotoxic stress.
UniGene ID
Hs.440900
UniProt ID (eCommerce)
P46379
Recently Viewed Products
Ad-CMV-Luc
Cat No: 1000
Ad-CMV-Akt1 (Myr)
Cat No: 1020
Ad-CMV-Akt1 (dn)
Cat No: 1021
Ad-CMV-Akt1 (wt)
Cat No: 1022
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.