human AXIN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AXIN1.
shADV-201855
Ad-h-AXIN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AXIN1 (axin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AXIN; PPP1R49
Description (Vector)
AXIN1 encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
8312
Gene Name (Vector)
axin 1
Gene Symbol
AXIN1
HGNC ID
HGNC:903
ORF Size (aa)
2481
ORF Size (bp)
2481 bp
RefSeq ID
NM_003502
RefSeq Synonyms
NM_181050, NM_003502, BC044648,
Species
human
UniGene ID
Hs.592082
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.