mouse AXIN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Axin1.
shADV-253470
Ad-m-AXIN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Axin1 (axin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI316800; Axin; Fu; fused; Kb; Ki; kinky; knobbly
Description (Vector)
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Gene ID
12005
Gene Name (Vector)
axin 1
Gene Symbol
Axin1
ORF Size (aa)
2499
ORF Size (bp)
2499 bp
RefSeq ID
NM_009733
RefSeq Synonyms
NM_009733, NM_001159598, BC113171,
Species
mouse
UniGene ID
Mm.23684
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.