human ARID4B shRNA silencing Adenovirus

Name 
Ad-h-ARID4B-shRNA
Cat No 
shADV-201383
Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human ARID4B.

shADV-201383
Ad-h-ARID4B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ARID4B (AT-rich interaction domain 4B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
180 kDa Sin3-associated polypeptide; ARID domain-containing protein 4B; AT rich interactive domain 4B (RBP1-like); AT-rich interactive domain-containing protein 4B; BCAA; BRCAA1; breast cancer-associated antigen 1; breast cancer-associated antigen BRCAA1; breast carcinoma-associated antigen; histone deacetylase complex subunit SAP180; Rb-binding protein homolog; RBBP1L1; RBP1L1; retinoblastoma-binding protein 1-like 1; SAP180; SIN3A-associated protein 180; sin3-associated polypeptide p180
Description (eCommerce)
ARID4B (AT-rich interactive domain-containing protein 4B) is also known as RbBP1L1 (retinoblastoma binding protein 1-like 1) and is a retinoblastoma binding protein and member of the AT-rich interaction domain (ARID) family of proteins. In addition to the ARID DNA binding domain, ARID4B also contains a chromo domain and a TUDOR domain, indicating a function in chromatin organization and protein-protein interactions with methylated protein substrates. As a subunit of the SIN3A transcriptional co-repressor, ARID4B is implicated to be involved in chromatin remodeling and epigenetic modifications. ARID4B may play a role in the pathogenesis of breast cancer and other malignancies.
Description (Vector)
ARID4B encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Gene ID
51742
Gene Name (eCommerce)
AT-rich interaction domain 4B
Gene Name (Vector)
AT-rich interaction domain 4B
Gene Symbol
ARID4B
HGNC ID
HGNC:15550
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3462
ORF Size (bp)
3462 bp
Protein Name (eCommerce)
AT-rich interactive domain-containing protein 4B
RefSeq ID
NM_016374
RefSeq Synonyms
NM_031371, NM_016374, NM_001206794, BC130418,
Research Areas
Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Immunology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation,immunology,genetics
Species
human
Target Sentence
ARID4B (AT-rich interactive domain-containing protein 4B) is also known as RbBP1L1 (retinoblastoma binding protein 1-like 1) and is a retinoblastoma binding protein and member of the AT-rich interaction domain (ARID) family of proteins. In addition to the ARID DNA binding domain, ARID4B also contains a chromo domain and a TUDOR domain, indicating a function in chromatin organization and protein-protein interactions with methylated protein substrates. As a subunit of the SIN3A transcriptional co-repressor, ARID4B is implicated to be involved in chromatin remodeling and epigenetic modifications. ARID4B may play a role in the pathogenesis of breast cancer and other malignancies.
UniGene ID
Hs.575782
UniProt ID (eCommerce)
Q4LE39

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.