human ARHGEF10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ARHGEF10.
shADV-201353
Ad-h-ARHGEF10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ARHGEF10 (Rho guanine nucleotide exchange factor 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GEF10; Rho guanine nucleotide exchange factor (GEF) 10; rho guanine nucleotide exchange factor 10; SNCV
Description (eCommerce)
Rho guanine nucleotide exchange factor (GEF) 10 (ARHGEF10) may play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15013].
Description (Vector)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals.
Gene ID
9639
Gene Name (eCommerce)
Rho guanine nucleotide exchange factor 10
Gene Name (Vector)
Rho guanine nucleotide exchange factor 10
Gene Symbol
ARHGEF10
HGNC ID
HGNC:14103
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3921
ORF Size (bp)
3921 bp
Protein Name (eCommerce)
Rho guanine nucleotide exchange factor 10
RefSeq ID
NM_014629
RefSeq Synonyms
NM_014629, NM_001308153, NM_001308152, BC112926, BC040474,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Neurodevelopment,Rho Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Rho guanine nucleotide exchange factor (GEF) 10 (ARHGEF10) may play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15013].
UniGene ID
Hs.98594
UniProt ID (eCommerce)
O15013
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.