human ANAPC4 shRNA silencing Adenovirus

Name 
Ad-h-ANAPC4-shRNA
Cat No 
shADV-200900
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ANAPC4.

shADV-200900
Ad-h-ANAPC4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ANAPC4 (anaphase promoting complex subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
anaphase-promoting complex subunit 4; APC4; cyclosome subunit 4
Description (eCommerce)
APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase that controls cell cycle progression and promotes the transition from metaphase to anaphase. The APC complex is composed of at least 11 APC components. The exact function of APC4 has not been determined.
Description (Vector)
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known.
Gene ID
29945
Gene Name (eCommerce)
anaphase promoting complex subunit 4
Gene Name (Vector)
anaphase promoting complex subunit 4
Gene Symbol
ANAPC4
HGNC ID
HGNC:19990
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2427
ORF Size (bp)
2427 bp
Protein Name (eCommerce)
Anaphase-promoting complex subunit 4
RefSeq ID
NM_013367
RefSeq Synonyms
NM_013367, NM_001286756, BC059383,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Host-Virus Interactions,Immunology,Meiosis,Signal Transduction,TGF-beta Signaling,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
APC4 is a component of the anaphase-promoting complex (APC). The APC complex functions as an ubiquitin ligase that controls cell cycle progression and promotes the transition from metaphase to anaphase. The APC complex is composed of at least 11 APC components. The exact function of APC4 has not been determined.
UniGene ID
Hs.152173
UniProt ID (eCommerce)
Q9UJX5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.