human AMOT shRNA silencing Adenovirus

Name 
Ad-h-AMOT-shRNA
Cat No 
shADV-200865
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human AMOT.

shADV-200865
Ad-h-AMOT-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human AMOT (angiomotin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
angiomotin; angiomotin p130 isoform; angiomotin p80 isoform
Description (eCommerce)
Angiomotin belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. Angiomotin is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels [taken from NCBI Entrez Gene (Gene ID: 154796)].
Description (Vector)
AMOT belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
154796
Gene Name (eCommerce)
angiomotin
Gene Name (Vector)
angiomotin
Gene Symbol
AMOT
HGNC ID
HGNC:17810
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2031
ORF Size (bp)
2031 bp
Protein Name (eCommerce)
Angiomotin
RefSeq ID
NM_133265
RefSeq Synonyms
NM_133265, NM_001113490, BC130294,
Research Areas
Angiogenesis,Cardiovascular,Cytoskeleton,Hippo Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,signal_transduction
Species
human
Target Sentence
Angiomotin belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. Angiomotin is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels [taken from NCBI Entrez Gene (Gene ID: 154796)].
UniGene ID
Hs.528051
UniProt ID (eCommerce)
Q4VCS5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.