human AKR1C3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AKR1C3.
shADV-200686
Ad-h-AKR1C3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AKR1C3 (aldo-keto reductase family 1 member C3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; PGFS
Description (Vector)
AKR1C3 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. AKR1C3 shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
8644
Gene Name (Vector)
aldo-keto reductase family 1 member C3
Gene Symbol
AKR1C3
HGNC ID
HGNC:386
ORF Size (aa)
972
ORF Size (bp)
972 bp
RefSeq ID
NM_003739
RefSeq Synonyms
NM_003739, NM_001253909, NM_001253908, BC019230, BC001479,
Species
human
UniGene ID
Hs.78183
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.