human AKAP8L shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human AKAP8L.
shADV-200667
Ad-h-AKAP8L-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human AKAP8L (A-kinase anchoring protein 8 like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A kinase (PRKA) anchor protein 8-like; AKAP8-like protein; A-kinase anchor protein 8-like; HA95; HAP95; Helicase A-binding protein 95; helicase A-binding protein 95 kDa; homologous to AKAP95 protein; NAKAP; NAKAP95; neighbor of AKAP95; neighbor of A-kinase anchoring protein 95; Neighbor of A-kinase-anchoring protein 95; testis tissue sperm-binding protein Li 90mP
Description (eCommerce)
AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
Gene ID
26993
Gene Name (eCommerce)
A-kinase anchoring protein 8 like
Gene Name (Vector)
A-kinase anchoring protein 8 like
Gene Symbol
AKAP8L
HGNC ID
HGNC:29857
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1941
ORF Size (bp)
1941 bp
Protein Name (eCommerce)
A-kinase anchor protein 8-like
RefSeq ID
NM_014371
RefSeq Synonyms
NM_014371, NM_001291478, BC000713,
Research Areas
Cell Cycle,Cell Division,Helicase Activity,Host-Virus Interactions,RNA Binding,RNA Processing,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington’s disease.
UniGene ID
Hs.399800
UniProt ID (eCommerce)
Q9ULX6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.