human ACY1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ACY1.
shADV-200334
Ad-h-ACY1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ACY1 (aminoacylase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACY-1; ACY1D; HEL-S-5
Description (Vector)
ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
Gene ID
95
Gene Name (Vector)
aminoacylase 1
Gene Symbol
ACY1
HGNC ID
HGNC:177
ORF Size (aa)
1227
ORF Size (bp)
1227 bp
RefSeq ID
NM_000666
RefSeq Synonyms
NM_001198898, NM_001198897, NM_001198896, NM_001198895, NM_000666, BC014112, BC003023, BC000545,
Species
human
UniGene ID
Hs.334707
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.