human ABAT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ABAT.
shADV-200039
Ad-h-ABAT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ABAT (4-aminobutyrate aminotransferase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GABA-AT; GABAT; NPD009
Description (Vector)
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Gene ID
18
Gene Name (Vector)
4-aminobutyrate aminotransferase
Gene Symbol
ABAT
HGNC ID
HGNC:23
ORF Size (aa)
1503
ORF Size (bp)
1503 bp
RefSeq ID
NM_000663
RefSeq Synonyms
NM_020686, NM_001127448, NM_000663, BC031413, BC015628, BC008990,
Species
human
UniGene ID
Hs.715664
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.