rat NUMBL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Numbl.
shAAV-294998
AAV-r-NUMBL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Numbl (NUMB-like, endocytic adaptor protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Gene ID
292732
Gene Name (Vector)
NUMB-like, endocytic adaptor protein
Gene Symbol
Numbl
ORF Size (aa)
1845
ORF Size (bp)
1845 bp
RefSeq ID
NM_001033888
RefSeq Synonyms
NM_001033888, BC129073,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.