human ITGAL Over-expression AAV

Name
AAV-h-ITGAL

Cat No
AAV-212491

Availability
4-5 weeks

This is an AAV expressing Human ITGAL.

AAV-212491

AAV-h-ITGAL

Ready-to-use AAV expressing Human ITGAL (integrin subunit alpha L). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD11A; LFA-1; LFA1A

Description (Vector)

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

3683

Gene Name (Vector)

integrin subunit alpha L

Gene Symbol

ITGAL

HGNC ID

HGNC:6148

ORF Size (aa)

3261

ORF Size (bp)

3261 bp

RefSeq ID

NM_002209

RefSeq Synonyms

NM_002209, NM_001114380, BC008777,

Species

human

UniGene ID

Hs.174103

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.