rat CDKN1A shRNA silencing AAV

Name
AAV-r-CDKN1A-shRNA

Cat No
shAAV-294363

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Cdkn1a.

shAAV-294363

AAV-r-CDKN1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Cdkn1a (cyclin-dependent kinase inhibitor 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Cip1; UV96; Waf1

Description (Vector)

CDKN1A may be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Gene ID

114851

Gene Name (Vector)

cyclin-dependent kinase inhibitor 1A

Gene Symbol

Cdkn1a

ORF Size (aa)

495

ORF Size (bp)

495 bp

RefSeq ID

NM_080782

RefSeq Synonyms

NM_080782, BC100620,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.