rat MAD2L2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Mad2l2.
shAAV-292632
AAV-r-MAD2L2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Mad2l2 (MAD2 mitotic arrest deficient-like 2 (yeast)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
Gene ID
313702
Gene Name (Vector)
MAD2 mitotic arrest deficient-like 2 (yeast)
Gene Symbol
Mad2l2
ORF Size (aa)
705
ORF Size (bp)
705 bp
RefSeq ID
NM_001012106
RefSeq Synonyms
NM_001012106, BC087687,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.