rat GNAS shRNA silencing AAV

Name
AAV-r-GNAS-shRNA

Cat No
shAAV-290535

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Rat Gnas.

shAAV-290535

AAV-r-GNAS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Gnas (GNAS complex locus). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALEX; Gnas1; Gnpas; Nesp55; SCG6

Description (Vector)

GNAS may inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame|Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)|Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli.

Gene ID

24896

Gene Name (Vector)

GNAS complex locus

Gene Symbol

Gnas

ORF Size (aa)

1185

ORF Size (bp)

1185 bp

RefSeq ID

NM_001159653

RefSeq Synonyms

NM_021845, NM_019132, NM_001159656, NM_001159653, NM_001024823, BC061967,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.