human IARS2 Over-expression AAV

Name
AAV-h-IARS2

Cat No
AAV-211739

Availability
4-5 weeks

This is an AAV expressing Human IARS2.

AAV-211739

AAV-h-IARS2

Ready-to-use AAV expressing Human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAGSSS; ILERS; isoleucine tRNA ligase 2, mitochondrial; isoleucine--tRNA ligase, mitochondrial; isoleucine-tRNA synthetase 2, mitochondrial; Isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase, mitochondrial; mitochondrial isoleucine tRNA synthetase

Description (eCommerce)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. IARS2 is the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family [taken from NCBI Entrez Gene (Gene ID: 55699)].

Gene ID

55699

Gene Name (eCommerce)

isoleucyl-tRNA synthetase 2, mitochondrial

Gene Name (Vector)

isoleucyl-tRNA synthetase 2, mitochondrial

Gene Symbol

IARS2

HGNC ID

HGNC:29685

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3039

ORF Size (bp)

3039 bp

Protein Name (eCommerce)

Isoleucine--tRNA ligase, mitochondrial

RefSeq ID

NM_018060

RefSeq Synonyms

NM_018060, BC137438, BC010218,

Research Areas

Gene Expression,Mitochondrion,Translational Control

Research Areas (Faceted)

cell_biology,transcription_translation

Species

human

Target Sentence

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. IARS2 is the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family [taken from NCBI Entrez Gene (Gene ID: 55699)].

UniGene ID

Hs.262823

UniProt ID (eCommerce)

Q9NSE4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.