mouse WEE2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Wee2.
shAAV-281204
AAV-m-WEE2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Wee2 (WEE1 homolog 2 (S. pombe)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Gm1065; Wee1B
Description (Vector)
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
Gene ID
381759
Gene Name (Vector)
WEE1 homolog 2 (S. pombe)
Gene Symbol
Wee2
ORF Size (aa)
1668
ORF Size (bp)
1668 bp
RefSeq ID
NM_201370
RefSeq Synonyms
NM_201370, BC080784, BC052883,
Species
mouse
UniGene ID
Mm.20593
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.