mouse DNAJB6 shRNA silencing AAV

Name
AAV-m-DNAJB6-shRNA

Cat No
shAAV-279172

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Dnajb6.

shAAV-279172

AAV-m-DNAJB6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dnajb6 (DnaJ heat shock protein family (Hsp40) member B6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

mDj4; Mrj

Description (Vector)

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.

Gene ID

23950

Gene Name (Vector)

DnaJ heat shock protein family (Hsp40) member B6

Gene Symbol

Dnajb6

ORF Size (aa)

729

RefSeq ID

NM_011847

RefSeq Synonyms

NM_011847, NM_001127367, NM_001037941, NM_001037940, BC083349, BC003702,

Species

mouse

UniGene ID

Mm.290110

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.