mouse DNAJB6 shRNA silencing AAV

Name 
AAV-m-DNAJB6-shRNA
Cat No 
shAAV-279172
Availability
Immediate
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Dnajb6.

shAAV-279172
AAV-m-DNAJB6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dnajb6 (DnaJ heat shock protein family (Hsp40) member B6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
50
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
mDj4; Mrj
Description (Vector)
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Gene ID
23950
Gene Name (Vector)
DnaJ heat shock protein family (Hsp40) member B6
Gene Symbol
Dnajb6
ORF Size (aa)
729
RefSeq ID
NM_011847
RefSeq Synonyms
NM_011847, NM_001127367, NM_001037941, NM_001037940, BC083349, BC003702,
Species
mouse
UniGene ID
Mm.290110

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.