human HSD3B2 Over-expression AAV

Name
AAV-h-HSD3B2

Cat No
AAV-211584

Availability
4-5 weeks

This is an AAV expressing Human HSD3B2.

AAV-211584

AAV-h-HSD3B2

Ready-to-use AAV expressing Human HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HSD3B; HSDB; SDR11E2

Description (Vector)

HSD3B2 is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene.

Gene ID

3284

Gene Name (Vector)

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Gene Symbol

HSD3B2

HGNC ID

HGNC:5218

ORF Size (aa)

1119

ORF Size (bp)

1119 bp

RefSeq ID

NM_000198

RefSeq Synonyms

NM_001166120, NM_000198, BC131488, BC038419,

Species

human

UniGene ID

Hs.654399

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.