mouse C4A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse C4a.
shAAV-277357
AAV-m-C4A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse C4a (complement component 4A (Rodgers blood group)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Slp; SlpA
Description (Vector)
C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway|Function: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Gene ID
625018
Gene Name (Vector)
complement component 4A (Rodgers blood group)
Gene Symbol
C4a
ORF Size (aa)
5208
ORF Size (bp)
5208 bp
RefSeq ID
NM_011413
RefSeq Synonyms
NM_011413, BC172697, BC156486, BC141050,
Species
mouse
UniGene ID
Mm.
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.