human C4A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human C4A.
shADV-203438
Ad-h-C4A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human C4A (complement C4A (Rodgers blood group)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C4; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG
Description (Vector)
C4A encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. C4A localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
720
Gene Name (Vector)
complement C4A (Rodgers blood group)
Gene Symbol
C4A
HGNC ID
HGNC:1323
ORF Size (aa)
5097
ORF Size (bp)
5097 bp
RefSeq ID
NM_007293
RefSeq Synonyms
NM_007293, NM_001252204, BC171786, BC151204, BC146849, BC146673, BC144546, BC063289,
Species
human
UniGene ID
Hs.534847
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.