mouse XPO1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Xpo1.
shAAV-276409
AAV-m-XPO1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Xpo1 (exportin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA420417; Crm1; Exp1
Description (Vector)
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
Gene ID
103573
Gene Name (Vector)
exportin 1
Gene Symbol
Xpo1
ORF Size (aa)
3216
ORF Size (bp)
3216 bp
RefSeq ID
NM_001035226
RefSeq Synonyms
NM_134014, NM_001035226, BC062912, BC025628, BC012276,
Species
mouse
UniGene ID
Mm.217547
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.