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human XPO1 Adenovirus

Name 
Ad-h-XPO1
Cat No 
ADV-227914
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human XPO1.

ADV-227914
Ad-h-XPO1

Ready-to-use Adenovirus expressing Human XPO1 (exportin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
chromosome region maintenance 1 homolog; chromosome region maintenance 1 protein homolog; CRM1; emb; exp1; exportin 1 (CRM1 homolog, yeast); exportin-1; exportin-1 (required for chromosome region maintenance)
Description (eCommerce)
Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.
Description (Vector)
XPO1 mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
Gene ID
7514
Gene Name (eCommerce)
exportin 1
Gene Name (Vector)
exportin 1
Gene Symbol
XPO1
HGNC ID
HGNC:12825
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3216
ORF Size (bp)
3216 bp
Protein Name (eCommerce)
Exportin-1
RefSeq ID
NM_003400
RefSeq Synonyms
NM_003400, BC032847,
Research Areas
Cell Cycle,FoxO Signaling,Gene Expression,Hedgehog Signaling,Host-Virus Interactions,Immunology,mRNA Binding,mRNA transport,NFAT Signaling,NF-kB Signaling,Nuclear Import/Export,RNA Binding,RNA Processing,RNA Transport,Signal Transduction,Spermatogenesis,TGF-beta Signaling,Transport
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,signal_transduction,developmental_biology,infectious_disease,immunology,genetics,transcription_translation,signal_transduction,immunology,cell_biology,genetics,transcription_translation,cell_biology,cell_cycle,signal_transduction,immunology,cell_biology
Species
human
Target Sentence
Chromosome region maintenance 1 protein homolog (CRM1) is the Ran-GTP-binding nuclear export receptor for proteins bearing a leucine rich nuclear export signal and RNAs. CRM1 also possesses a mitotic function as it localizes to kinetochores, and with Ran-GTP, recruits Ran-GTPase-activating protein (Ran-GAP1) and Ran-binding protein (Ran-BP2) for proper mitotic spindle assembly and chromosome segregation. Additionally, CRM1 is suggested to function as a loading dock of various cell cycle and checkpoint factors such as cyclins, Cdks, p53 and BRCA1, to regulate proper chromosome duplication and genomic stability.
UniGene ID
Hs.370770
UniProt ID (eCommerce)
O14980

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.