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mouse UBR2 shRNA silencing AAV

Name 
AAV-m-UBR2-shRNA
Cat No 
shAAV-275544
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Ubr2.

shAAV-275544
AAV-m-UBR2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ubr2 (ubiquitin protein ligase E3 component n-recognin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9930021A08Rik; AI462103; AW540746; E130209G04Rik; ENSMUSG00000043296; mKIAA0349
Description (Vector)
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Gene ID
224826
Gene Name (Vector)
ubiquitin protein ligase E3 component n-recognin 2
Gene Symbol
Ubr2
ORF Size (aa)
5268
ORF Size (bp)
5268 bp
RefSeq ID
NM_146078
RefSeq Synonyms
NM_146078, NM_001177374, BC075642, BC031403,
Species
mouse
UniGene ID
Mm.28234

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.