mouse TNFRSF11B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tnfrsf11b.
shAAV-274691
AAV-m-TNFRSF11B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tnfrsf11b (tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
OCIF; Opg; TR1
Description (Vector)
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Gene ID
18383
Gene Name (Vector)
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Gene Symbol
Tnfrsf11b
ORF Size (aa)
1206
ORF Size (bp)
1206 bp
RefSeq ID
NM_008764
RefSeq Synonyms
NM_008764, BC049782,
Species
mouse
UniGene ID
Mm.15383
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.