mouse DKK4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Dkk4.
shAAV-257210
AAV-m-DKK4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Dkk4 (dickkopf WNT signaling pathway inhibitor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Dkk-4
Description (Vector)
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Gene ID
234130
Gene Name (Vector)
dickkopf WNT signaling pathway inhibitor 4
Gene Symbol
Dkk4
ORF Size (aa)
666
ORF Size (bp)
666 bp
RefSeq ID
NM_145592
RefSeq Synonyms
NM_145592, BC018400,
Species
mouse
UniGene ID
Mm.157322
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.