mouse SUMO1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Sumo1.
shAAV-273461
AAV-m-SUMO1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Sumo1 (small ubiquitin-like modifier 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3; SMTP3; SUMO-1; Ubl1
Description (Vector)
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.
Gene ID
22218
Gene Name (Vector)
small ubiquitin-like modifier 1
Gene Symbol
Sumo1
ORF Size (aa)
306
RefSeq ID
NM_009460
RefSeq Synonyms
NM_009460, BC083158, BC082566,
Species
mouse
UniGene ID
Mm.362118
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.