mouse SH3RF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Sh3rf1.
shAAV-271919
AAV-m-SH3RF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Sh3rf1 (SH3 domain containing ring finger 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2200003J05Rik; Posh; R75531; Sh3md2
Description (Vector)
Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane|Function: Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis|Function: Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.
Gene ID
59009
Gene Name (Vector)
SH3 domain containing ring finger 1
Gene Symbol
Sh3rf1
ORF Size (aa)
2586
ORF Size (bp)
2586 bp
RefSeq ID
NM_021506
RefSeq Synonyms
NM_021506, BC060696, BC060113,
Species
mouse
UniGene ID
Mm.27949
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.