mouse RNASEL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rnasel.
shAAV-270655
AAV-m-RNASEL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rnasel (ribonuclease L (2′, 5′-oligoisoadenylate synthetase-dependent)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E230029I04Rik
Description (Vector)
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA. turnover.
Gene ID
24014
Gene Name (Vector)
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Gene Symbol
Rnasel
ORF Size (aa)
2208
ORF Size (bp)
2208 bp
RefSeq ID
NM_011882
RefSeq Synonyms
NM_011882, BC138013,
Species
mouse
UniGene ID
Mm.259254
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.