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human HBG2 Over-expression AAV

Name 
AAV-h-HBG2
Cat No 
AAV-210823
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HBG2.

AAV-210823
AAV-h-HBG2

Ready-to-use AAV expressing Human HBG2 (hemoglobin subunit gamma 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HBG-T1; TNCY
Description (Vector)
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Gene ID
3048
Gene Name (Vector)
hemoglobin subunit gamma 2
Gene Symbol
HBG2
HGNC ID
HGNC:4832
ORF Size (aa)
444
RefSeq ID
NM_000184
RefSeq Synonyms
NM_000184, BC130459, BC130457, BC029387,
Species
human
UniGene ID
Hs.302145

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.