human GTF3C2 Over-expression AAV

Name 
AAV-h-GTF3C2
Cat No 
AAV-210653
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GTF3C2.

AAV-210653
AAV-h-GTF3C2

Ready-to-use AAV expressing Human GTF3C2 (general transcription factor IIIC subunit 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
general transcription factor 3C polypeptide 2; general transcription factor IIIC, polypeptide 2, beta 110kDa; TF3C-beta; TFIIIC 110 kDa subunit; TFIIIC110; TFIIIC-BETA; transcription factor IIIC 110 kDa subunit; transcription factor IIIC subunit beta
Description (eCommerce)
General transcription factor 3C polypeptide 2 (GTF3C2/TFIIIC110) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. The functional contribution of GTF3C2/TFIIIC110 to the TFIIIC complex has not been fully determined. TFIIIC that is not associated with GTF3C2/TFIIIC110 has been purified, and it has been proposed that GTF3C2/TFIIIC110 functions to activate the TFIIIC complex for RNA polymerase III transcription. Recent studies argue against this model of GTF3C2/TFIIIC110 function.
Gene ID
2976
Gene Name (eCommerce)
general transcription factor IIIC subunit 2
Gene Name (Vector)
general transcription factor IIIC subunit 2
Gene Symbol
GTF3C2
HGNC ID
HGNC:4665
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2736
ORF Size (bp)
2736 bp
Protein Name (eCommerce)
General transcription factor 3C polypeptide 2
RefSeq ID
NM_001521
RefSeq Synonyms
NM_001521, NM_001318909, NM_001035521, BC020981, BC000212,
Research Areas
Gene Expression,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
General transcription factor 3C polypeptide 2 (GTF3C2/TFIIIC110) is a subunit of the TFIIIC DNA-binding factor required for transcription of tRNA and 5S rRNA genes by RNA polymerase III. Human TFIIIC is composed of six subunits: TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, and TFIIIC35. The functional contribution of GTF3C2/TFIIIC110 to the TFIIIC complex has not been fully determined. TFIIIC that is not associated with GTF3C2/TFIIIC110 has been purified, and it has been proposed that GTF3C2/TFIIIC110 functions to activate the TFIIIC complex for RNA polymerase III transcription. Recent studies argue against this model of GTF3C2/TFIIIC110 function.
UniGene ID
Hs.75782
UniProt ID (eCommerce)
Q8WUA4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.