human GTF2IRD1 Over-expression AAV

Name 
AAV-h-GTF2IRD1
Cat No 
AAV-210650
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GTF2IRD1.

AAV-210650
AAV-h-GTF2IRD1

Ready-to-use AAV expressing Human GTF2IRD1 (GTF2I repeat domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BEN; binding factor for early enhancer; CREAM1; general transcription factor 3; general transcription factor III; general transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; GTF3; hMusTRD1alpha1; Muscle TFII-I repeat domain-containing protein 1; muscle TFII-I repeat domain-containing protein 1 alpha 1; MUSTRD1; MusTRD1/BEN; RBAP2; slow-muscle-fiber enhancer-binding protein; USE B1-binding protein; WBS; WBSCR11; WBSCR12; Williams-Beuren syndrome chromosomal region 11 protein; williams-Beuren syndrome chromosomal region 12 protein; Williams-Beuren syndrome chromosome region 11
Description (eCommerce)
GTF2IRD1/TFII-IRD1 possesses five helix-loop-helix GTF2I-like repeats and has been shown to bind the GUCE (GTF2IRD1 upstream response element) regulatory motif found in HOXC8, GOOSECOID, and TROPONININ (SLOW) genes. GTF2IRD1/TFII-IRD1 may be involved in skeletal muscle differentiation and myogenesis. Haploinsufficiency of GTF2IRD1/TFII-IRD1 results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
Description (Vector)
GTF2IRD1 contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.
Gene ID
9569
Gene Name (eCommerce)
GTF2I repeat domain containing 1
Gene Name (Vector)
GTF2I repeat domain containing 1
Gene Symbol
GTF2IRD1
HGNC ID
HGNC:4661
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2880
ORF Size (bp)
2880 bp
Protein Name (eCommerce)
General transcription factor II-I repeat domain-containing protein 1
RefSeq ID
NM_005685
RefSeq Synonyms
NM_016328, NM_005685, NM_001199207, BC018136,
Research Areas
Host-Virus Interactions,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
GTF2IRD1/TFII-IRD1 possesses five helix-loop-helix GTF2I-like repeats and has been shown to bind the GUCE (GTF2IRD1 upstream response element) regulatory motif found in HOXC8, GOOSECOID, and TROPONININ (SLOW) genes. GTF2IRD1/TFII-IRD1 may be involved in skeletal muscle differentiation and myogenesis. Haploinsufficiency of GTF2IRD1/TFII-IRD1 results in Williams-Beuren syndrome (WBS), a rare developmental disorder characterized by musculo-skeletal and cardiac abnormalities.
UniGene ID
Hs.647056
UniProt ID (eCommerce)
Q9UHL9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.