mouse OTOF shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Otof.
shAAV-267745
AAV-m-OTOF-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Otof (otoferlin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).
Gene ID
83762
Gene Name (Vector)
otoferlin
Gene Symbol
Otof
ORF Size (aa)
5934
ORF Size (bp)
5934 bp
RefSeq ID
NM_031875
RefSeq Synonyms
NM_031875, NM_001313767, NM_001286421, NM_001100395, BC150702, BC145107,
Species
mouse
UniGene ID
Mm.244502
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.