human GRID2 Over-expression AAV

Name 
AAV-h-GRID2
Cat No 
AAV-210511
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GRID2.

AAV-210511
AAV-h-GRID2

Ready-to-use AAV expressing Human GRID2 (glutamate ionotropic receptor delta type subunit 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GluD2; SCAR18
Description (Vector)
Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.
Gene ID
2895
Gene Name (Vector)
glutamate ionotropic receptor delta type subunit 2
Gene Symbol
GRID2
HGNC ID
HGNC:4576
ORF Size (aa)
2739
ORF Size (bp)
2739 bp
RefSeq ID
NM_001510
RefSeq Synonyms
NM_001510, NM_001286838, BC099654, BC099653, BC099652,
Species
human
UniGene ID
Hs.480281

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.