human GRID2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GRID2.
shAAV-210511
AAV-h-GRID2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GRID2 (glutamate ionotropic receptor delta type subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GluD2; SCAR18
Description (Vector)
Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.
Gene ID
2895
Gene Name (Vector)
glutamate ionotropic receptor delta type subunit 2
Gene Symbol
GRID2
HGNC ID
HGNC:4576
ORF Size (aa)
2739
ORF Size (bp)
2739 bp
RefSeq ID
NM_001510
RefSeq Synonyms
NM_001510, NM_001286838, BC099654, BC099653, BC099652,
Species
human
UniGene ID
Hs.480281
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.