mouse NTAN1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ntan1.
shAAV-266142
AAV-m-NTAN1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ntan1 (N-terminal Asn amidase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PNAA; PNAD
Description (Vector)
Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position (By similarity).
Gene ID
18203
Gene Name (Vector)
N-terminal Asn amidase
Gene Symbol
Ntan1
ORF Size (aa)
933
RefSeq ID
NM_010946
RefSeq Synonyms
NM_010946, NM_001346111, NM_001346110, NM_001346109, NM_001346108, NM_001346107, NM_001346106, BC030172,
Species
mouse
UniGene ID
Mm.380410
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.