mouse NFKBIB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Nfkbib.
shAAV-265726
AAV-m-NFKBIB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Nfkbib (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
I(Kappa)B(beta); I-kappa-B-beta; IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB
Description (Vector)
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Gene ID
18036
Gene Name (Vector)
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
Gene Symbol
Nfkbib
ORF Size (aa)
1080
ORF Size (bp)
1080 bp
RefSeq ID
NM_010908
RefSeq Synonyms
NM_010908, NM_001306222, BC021938,
Species
mouse
UniGene ID
Mm.220333
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.