mouse MFN2 shRNA silencing AAV

Name
AAV-m-MFN2-shRNA

Cat No
shAAV-264560

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Mfn2.

shAAV-264560

AAV-m-MFN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mfn2 (mitofusin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D630023P19Rik; Fzo

Description (Vector)

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation.

Gene ID

170731

Gene Name (Vector)

mitofusin 2

Gene Symbol

Mfn2

ORF Size (aa)

2274

ORF Size (bp)

2274 bp

RefSeq ID

NM_133201

RefSeq Synonyms

NM_133201, NM_001285923, NM_001285922, NM_001285921, NM_001285920, BC046503,

Species

mouse

UniGene ID

Mm.154312

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.