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mouse KCNQ5 shRNA silencing AAV

Name 
AAV-m-KCNQ5-shRNA
Cat No 
shAAV-262708
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Kcnq5.

shAAV-262708
AAV-m-KCNQ5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Kcnq5 (potassium voltage-gated channel, subfamily Q, member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
72
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
7730402H11; 9230107O05Rik; AA589396; D1Mgi1
Description (Vector)
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors.
Gene ID
226922
Gene Name (Vector)
potassium voltage-gated channel, subfamily Q, member 5
Gene Symbol
Kcnq5
ORF Size (aa)
2799
ORF Size (bp)
2799 bp
RefSeq ID
NM_023872
RefSeq Synonyms
NM_023872, NM_001310477, NM_001160139, BC157041, BC156308,
Species
mouse
UniGene ID
Mm.403737

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.