human GLRX3 Over-expression AAV

Name 
AAV-h-GLRX3
Cat No 
AAV-209999
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GLRX3.

AAV-209999
AAV-h-GLRX3

Ready-to-use AAV expressing Human GLRX3 (glutaredoxin 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GLRX4; glutaredoxin 4; glutaredoxin-3; GRX3; GRX4; PICOT; PKC-interacting cousin of thioredoxin; PKCq-interacting protein; PKC-theta-interacting protein; testicular tissue protein Li 75; thioredoxin-like protein 2; TXNL2; TXNL3
Description (eCommerce)
The gene GLRX3 encodes for the protein, Glutaredoxin-3. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. Glutaredoxin-3 may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer [taken from NCBI Entrez Gene (Gene ID: 10539)].
Description (Vector)
GLRX3 encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
10539
Gene Name (eCommerce)
glutaredoxin 3
Gene Name (Vector)
glutaredoxin 3
Gene Symbol
GLRX3
HGNC ID
HGNC:15987
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Glutaredoxin-3
RefSeq ID
NM_006541
RefSeq Synonyms
NM_006541, NM_001321980, NM_001199868, BC014372, BC005289,
Research Areas
Cardiac Hypertrophy,Cardiology,Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
The gene GLRX3 encodes for the protein, Glutaredoxin-3. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. Glutaredoxin-3 may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer [taken from NCBI Entrez Gene (Gene ID: 10539)].
UniGene ID
Hs.42644
UniProt ID (eCommerce)
O76003

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.