human GLRX Over-expression AAV

Name 
AAV-h-GLRX
Cat No 
AAV-209995
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GLRX.

AAV-209995
AAV-h-GLRX

Ready-to-use AAV expressing Human GLRX (glutaredoxin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GRX; GRX1
Description (Vector)
GLRX encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
Gene ID
2745
Gene Name (Vector)
glutaredoxin
Gene Symbol
GLRX
HGNC ID
HGNC:4330
ORF Size (aa)
321
RefSeq ID
NM_002064
RefSeq Synonyms
NM_002064, NM_001243659, NM_001243658, NM_001118890, BC106075, BC010965, BC005304,
Species
human
UniGene ID
Hs.712696

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.