human GHR Over-expression AAV

Name 
AAV-h-GHR
Cat No 
AAV-209864
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GHR.

AAV-209864
AAV-h-GHR

Ready-to-use AAV expressing Human GHR (growth hormone receptor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GHBP;
Description (Vector)
GHR encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
Gene ID
2690
Gene Name (Vector)
growth hormone receptor
Gene Symbol
GHR
HGNC ID
HGNC:4263
ORF Size (aa)
1356
ORF Size (bp)
1356 bp
RefSeq ID
NM_000163
RefSeq Synonyms
NM_001242462, NM_001242461, NM_001242460, NM_001242406, NM_001242405, NM_001242404, NM_001242403, NM_001242402, NM_001242401, NM_001242400, NM_001242399, NM_000163, BC136496,
Species
human
UniGene ID
Hs.684631

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.