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mouse GCK shRNA silencing AAV

Name 
AAV-m-GCK-shRNA
Cat No 
shAAV-259983
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Gck.

shAAV-259983
AAV-m-GCK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Gck (glucokinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Gk; GLK; Gls006; HK4; HKIV; Hlb62; HXKP; MODY2
Description (Vector)
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene ID
103988
Gene Name (Vector)
glucokinase
Gene Symbol
Gck
ORF Size (aa)
1398
ORF Size (bp)
1398 bp
RefSeq ID
NM_010292
RefSeq Synonyms
NM_010292, NM_001287386, BC011139,
Species
mouse
UniGene ID
Mm.220358

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.