mouse GABBR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Gabbr1.
shAAV-259789
AAV-m-GABBR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Gabbr1 (gamma-aminobutyric acid (GABA) B receptor, 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bM573K1.1; GABAB1; GABAbR1
Description (Vector)
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen|Function: Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
Gene ID
54393
Gene Name (Vector)
gamma-aminobutyric acid (GABA) B receptor, 1
Gene Symbol
Gabbr1
ORF Size (aa)
2883
ORF Size (bp)
2883 bp
RefSeq ID
NM_019439
RefSeq Synonyms
NM_019439, BC056990, BC054735,
Species
mouse
UniGene ID
Mm.32191
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.