human GABBR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human GABBR1.
shAAV-209497
AAV-h-GABBR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GABABR1; GABBR1-3; GB1; GPRC3A
Description (Vector)
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic (GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants.
Gene ID
2550
Gene Name (Vector)
gamma-aminobutyric acid type B receptor subunit 1
Gene Symbol
GABBR1
HGNC ID
HGNC:4070
ORF Size (aa)
2535
ORF Size (bp)
2535 bp
RefSeq ID
NM_001470
RefSeq Synonyms
NM_021904, NM_021903, NM_001470, NM_001319053, BC050532, BC042598, BC041332,
Species
human
UniGene ID
Hs.167017
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.