human GBA Over-expression AAV

Name
AAV-h-GBA

Cat No
AAV-209700

Availability
4-5 weeks

This is an AAV expressing Human GBA.

AAV-209700

AAV-h-GBA

Ready-to-use AAV expressing Human GBA (glucosylceramidase beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GBA1; GCB; GLUC

Description (Vector)

GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Gene ID

2629

Gene Name (Vector)

glucosylceramidase beta

Gene Symbol

GBA

HGNC ID

HGNC:4177

ORF Size (aa)

1611

ORF Size (bp)

1611 bp

RefSeq ID

NM_000157

RefSeq Synonyms

NM_001171812, NM_001171811, NM_001005742, NM_001005741, NM_000157, BC003356,

Species

human

UniGene ID

Hs.282997

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.