mouse DNM1L shRNA silencing AAV

Name
AAV-m-DNM1L-shRNA

Cat No
shAAV-257348

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Dnm1l.

shAAV-257348

AAV-m-DNM1L-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Dnm1l (dynamin 1-like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

6330417M19Rik; AI450666; Dlp1; Dnmlp1; Drp1; python

Description (Vector)

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport|Function: Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Gene ID

74006

Gene Name (Vector)

dynamin 1-like

Gene Symbol

Dnm1l

ORF Size (aa)

1839

ORF Size (bp)

1839 bp

RefSeq ID

NM_152816

RefSeq Synonyms

NM_152816, NM_001276341, NM_001276340, NM_001025947, BC079635, BC040777,

Species

mouse

UniGene ID

Mm.218820

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.